Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 1.628


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL1chr11_-_656678600.502.8e-15Click!
JUNDchr19_-_18392048-0.252.0e-04Click!
JUNBchr19_+_12902295-0.211.9e-03Click!
FOSchr14_+_75745480-0.152.5e-02Click!
FOSBchr19_+_45971249-0.127.3e-02Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_223889253 64.017 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr18_+_21452981 43.779 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr3_-_149095413 39.956 TM4SF1
transmembrane 4 L six family member 1
chr1_+_156084565 39.685 LMNA
lamin A/C
chr1_+_156084541 39.127 LMNA
lamin A/C
chr12_+_13349601 37.633 NM_001423
EMP1
epithelial membrane protein 1
chr3_-_149095517 36.573 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095458 35.896 TM4SF1
transmembrane 4 L six family member 1
chr1_+_156084458 34.716 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr3_-_149095333 33.347 TM4SF1
transmembrane 4 L six family member 1
chr6_+_83072922 31.453 NM_006670
TPBG
trophoblast glycoprotein
chr12_+_13349720 31.238 EMP1
epithelial membrane protein 1
chr12_-_53343607 29.870 KRT8
keratin 8
chr1_-_95007139 26.822 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr7_+_73245192 25.525 NM_001305
CLDN4
claudin 4
chr2_-_216259197 25.482 FN1
fibronectin 1
chr6_-_138428477 23.100 NM_022121
PERP
PERP, TP53 apoptosis effector
chr5_+_150020201 22.813 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_+_183155393 21.650 LAMC2
laminin, gamma 2
chr16_-_69760444 21.272 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
9.63 2.94e-02 GO:0031581 hemidesmosome assembly
4.66 2.46e-03 GO:0006521 regulation of cellular amino acid metabolic process
3.86 2.73e-02 GO:0033238 regulation of cellular amine metabolic process
3.53 4.23e-02 GO:0048871 multicellular organismal homeostasis
3.07 2.04e-05 GO:0008544 epidermis development
2.87 2.93e-02 GO:0032496 response to lipopolysaccharide
2.69 4.40e-03 GO:0007517 muscle organ development
2.59 1.78e-04 GO:0061061 muscle structure development
2.16 2.08e-09 GO:0009888 tissue development
2.14 1.30e-05 GO:0042060 wound healing
2.09 1.07e-04 GO:0050878 regulation of body fluid levels
2.03 6.80e-03 GO:0048870 cell motility
2.03 6.80e-03 GO:0051674 localization of cell
2.02 1.83e-03 GO:0008284 positive regulation of cell proliferation
2.01 4.60e-03 GO:0007596 blood coagulation
2.01 4.60e-03 GO:0050817 coagulation
2.00 3.21e-02 GO:0016477 cell migration
1.99 1.56e-05 GO:0007155 cell adhesion
1.99 1.56e-05 GO:0022610 biological adhesion
1.99 5.59e-03 GO:0007599 hemostasis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
9.80 2.16e-02 GO:0005838 proteasome regulatory particle
7.56 3.35e-04 GO:0001533 cornified envelope
4.48 1.09e-04 GO:0000502 proteasome complex
3.12 1.87e-03 GO:0044420 extracellular matrix part
2.98 4.87e-02 GO:0016327 apicolateral plasma membrane
2.89 9.97e-03 GO:0030016 myofibril
2.88 2.26e-05 GO:0005911 cell-cell junction
2.87 6.91e-03 GO:0043292 contractile fiber
2.81 2.35e-02 GO:0044449 contractile fiber part
2.57 7.42e-03 GO:0070161 anchoring junction
2.38 9.20e-03 GO:0030141 stored secretory granule
2.24 1.57e-02 GO:0016323 basolateral plasma membrane
1.91 3.21e-02 GO:0031012 extracellular matrix
1.87 8.76e-04 GO:0030054 cell junction
1.81 5.61e-05 GO:0005626 insoluble fraction
1.78 2.40e-04 GO:0005624 membrane fraction
1.63 4.51e-04 GO:0000267 cell fraction
1.55 1.36e-02 GO:0044421 extracellular region part
1.50 1.39e-03 GO:0005856 cytoskeleton
1.46 6.23e-05 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.56 2.80e-02 GO:0061135 endopeptidase regulator activity
2.54 4.51e-02 GO:0004866 endopeptidase inhibitor activity
1.78 2.36e-02 GO:0008092 cytoskeletal protein binding
1.59 7.44e-03 GO:0005102 receptor binding
1.27 3.72e-09 GO:0005515 protein binding
1.11 5.06e-04 GO:0005488 binding